| 1. | When treatment is deemed necessary the second difficult issue is whether to use interferon or analogues
治疗时必需面对的第二个棘手的问题是是否使用干扰素或核苷类似物。 |
| 2. | Fatal lactic acidosis has been reported to patients who received didanosine and other antiretroviral agents
有报道同时应用核苷类似物的患者可能发生乳酸酸中毒，有时是致命的。 |
| 3. | Mechanism of action : stavudine , a nucleoside analogue of thymidine , inhibits the replication of hiv in human cells in vitro
司他夫定是胸苷核苷类似物，可抑制hiv病毒在人体细胞内的复制。 |
| 4. | Because we know that treatment for hbv with analogues would be a very long term therapy , so their pre - resistance will be a very important one
因为我们知道慢乙肝用核苷类似物进行治疗是一个长期的过程，所以基线耐药是很重要的考虑因素。 |
| 5. | Viral dynamic studies showed more rapid decline of serum hbv - dna and eventually viral eradication in combination therapy of two different nucleoside analogues
病毒动力学研究表明：通过两种不同的核苷类似物联合治疗，血清中的hbv - dna含量会快速下降，最终彻底消除。 |
| 6. | Background : in chronic hepatitis b , long - term use of alpha interferon is hampered by side effects , and long - term treatment with nucleos ( t ) ide analogues is burdened by drug - resistant mutants
背景：慢性乙型肝炎治疗，长期使用-干扰素有副作用，而使用核苷类似物进行长期治疗容易出现抗药性突变体。 |
| 7. | My first question is if hbv nucleoside analogues happened with the resistance there , then the solution is to add - on other nucleoside drugs for combination therapy , or switch another nucleoside drugs
《国际肝病》 ：乙肝用核苷类似物出现耐药后，是加用其他核苷类药物，还是转换另外一种核苷类药物？ |
| 8. | Q : my first question is if hbv nucleoside analogues happened with the resistance there , then the solution is to add - on other nucleoside drugs for combination therapy , or switch another nucleoside drugs
《国际肝病》 ：乙肝用核苷类似物出现耐药后，是加用其他核苷类药物，还是转换另外一种核苷类药物？ |
| 9. | 《 international hepatis 》 ： regarding to nucleoside analogs with hepatitis b antiviral treatment , the drug - resistance raised genetic barriers they , how do you understand genetic resistance barrier ? do you agree
《国际肝病》 ：关于抗乙肝病毒治疗的核苷类似物，药物耐药性导致基因屏障概念的提出，你如何理解基因耐药性屏障？你同意这种说法吗？ |
| 10. | 《 hepatology digest 》 ： now the interferon therapy is definite therapy , do you think our patients with chronic hepatitis b must accept the peginterferon therapy before they accept the nucleotides analogues treatment
《国际肝病》 ：目前干扰素治疗慢乙肝具有肯定的疗效，你认为慢性乙型肝炎患者在接受核苷类似物之前是否必须接受长效干扰素治疗？ |
