Norepinephrine ( ne ) - evoked contraction was observed in rat aorta by using routine blood vascular perfusion in vitro . the experimental designs were as follows : 1 本课题利用去甲肾上腺素引起的血管收缩模型，通过常规离体血管灌流技术研究了阴离子通道对血管张力的调节及其机制。
2.
These results suggest : 1 ) anion channels play an important role in the regulation of blood vascular tone ; 2 ) ne - stimulated contraction is not influenced by extracellular sodium ; 3 ) vascular tone can be affected by anion channel ' s activity ; 4 ) the activation of anion channels do not depend on release of intracellular calcium ; 5 ) anion channels may be involved in the regulation of vascular tone through modulating the influx of extracellular calcium and the release of intracellular calcium 阴离子通道对血管平滑肌细胞外钙内流和内钙释放都有调节作用。本研究表明，血管张力的维持可能主要与阴离子通道的活动状态有关。阴离子通道很可能是通过调节血管平滑肌细胞外钙内流和内钙释放两个途径来发挥调节血管张力的作用。
