17 - hsd8 / pcdna3 . 1 recombinant protein expressed in hek 293 cells and it can slightly interconvert estrone to estradiol . moreover , it can catalyze the conversion from testosterone to androstenedione . however , 17 - hsd3 did n ' t show any conversion to all the substrates checked in this study 而17p一hsds转染hek293细胞表达的17p一hsds / pcdna3 . 1重组蛋白能微弱地催化el和ez之间的相互转化,同时也能催化从t到a的氧化反应。