| 1. | Antimalarial quality monitor in yunnan province
云南省抗疟疾药物质量监测分析 |
| 2. | In addition to effective antimalarial drugs , close monitoring and adequate supportive treatment in an intensive care unit are usually mandatory for patients with severe falciparum malaria infection
对严重的恶性疟疾感染，除了有效的抗疟疾药物治疗外，也往往需要重症加护单位严密的监控及适当的支持性疗法。 |
| 3. | By 1970 ddt spraying , elimination of mosquito breeding sites and the expanded use of antimalarial drugs freed more than 500 million people , or roughly one third of those previously living under malaria ' s cloud
到了1970年，由于喷? ddt 、清除蚊子繁殖地，以及扩大使用抗疟药物，超过五亿人得以免受疟疾的威胁，约略是原先生活在疟疾阴影下人口的1 / 3 。 |
| 4. | Screening target ' gene of artemisinin antimalarials using drug - western from cdna expressing library : 12 b - deoxoartemisinyl - ( 4 ' - oxyacetic acid ) phenyl ether was linked to bsa by using of edc cross ! inker and the product acted as drug - probe
对重组pmd一18一t克隆载体及pqe一30表达载体双酶切，提取tctp基因和pqe一30空载体并使二者重组，然后转化m15 ，挑取阳 |
| 5. | They include oral rehydration therapy , antibiotics , antimalarial drugs and insecticide - treated bednets , vitamin a and other micronutrients , promotion of breastfeeding , immunization , and skilled care during pregnancy and childbirth
这些干预包括口服补液疗法，抗菌素，抗疟疾药和经杀虫剂处理过的蚊帐，维生素a和其它营养素，促进母乳喂养，免疫以及妊娠和分娩期间的熟练照护。 |
| 6. | Lots of pharmacological and clinical experiments indicate that artemisinin is high effective with low toxicity . evidences from many laboratories suggest that the antimalarial function of artemisinin depends on the cleavage of the endoperoxide by binding to intraparasitic heme
虽然目前还没有直接证据表明虫体内蛋白质烷化是虫体致死的原因，但烷化蛋白与青蒿素类药物抗疟作用有关是很明显的。 |
| 7. | Artemisinin was originally isolated from artemisia annua , a herb used as the ancient chinese herbal remedy . artemisinin and its derivatives are new types of antimalarial with stable endoperoxide bridges differing from others , for instance chloroquine
青蒿素类药物是一种与已知抗疟药如氯喹等完全不同的新型化合物。大量药理及临床研究证明青蒿素类药物是优于氯喹的抗疟新药，具有速效、低毒、高效等特点。 |
| 8. | Now qinghaosu and some of it ' s derivatives are being used around the world as effective new antimalarial drugs in the fight against falciparum malaria , including multi - drug - resistant plasmodium falciparum . in addition , recent studies also indicate that some qinghaosu derivatives have other bioactivities , including antiparasitic and anticancer activities
国内外大量理化试验、药理研究和临床应用表明青蒿素是抗疟的有效成分，认为青蒿素的发现是抗疟史上的重大突破，最近，美国和欧洲的一些实验室研究表明青蒿素还具有抗癌的活性。 |
| 9. | Subsequently . it has been found in all normal cells examined so far except the kidney cells . tctp homologues among the species are highly conserved , which suggest that the protein might have an essential function in cell . lt was reported that tctp caused the release of histamine from ige + basophils and was capable of various functions including calcium binding . metal homeostasis , intracellular signaling and reacting with antimalarial drugs
从植物到动物的各类细胞中， tctp都有广泛的高度同源性和高度保守性，提示tctp在细胞中有重要的生物学功能。虽然报道认为tctp具有钙结合、金属内环境稳定、细胞内信号传导、作为ige依赖性组胺释放因子等功能，但其具体生物学功能尚待进一步研究阐明。 |
| 10. | Since the middle of 20th century chinese scientists have put considerable effort and resources into the search for new antimalarial compounds extracted from chinese traditional herbs . an antimalarial drug was finally isolated in 1971 and named artemisinin or qinghaosu . its rapid action , low toxicity and powerful effect against falciparum malaria made it a favored subject for research
青蒿素是一种含过氧基团组成缩酮的新倍半萜内酯，我国科学工作者于二十世纪70年代首次从中药青蒿即菊科植物黄花蒿( artemisiaannua )中分离出青蒿素。 |
