Recently drugs that act on cannabinoid receptors ? the ones that mediate marijuana ' s effects ? have been advancing through clinical trials 最近，作用于大麻素受体的药物也进入了临床试验；大麻素受体是大麻在人体内作用的位置。
2.
Pag , hippocampus etc . ) and inhibiting ca2 + currents hi rat hippocampal and dorsal root ganglion neurons . immunohistochemical and in situ hybridization histochemical studies have demonstrated orl1 receptor , cannabinoid receptor and their ligands are densely distributed in the superficial doral hom of the spinal cord 免疫组织化学和原位分子杂交实验结果显示这两类受体及其配体在脊髓背角浅层均有大量的分布( antonetal . , 1996 ; farquhar - smithetal . , 2000 ) 。
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According to behavioral studies in adult rats , intrathecal administration of nociceptin , anandamide and win - 55 , 212 ( win - 2 ) ( cannabinoid receptor agonists ) produces an antinoceptive effect in versatile pain models including acute , tonic and chronic pain models ( see mogil & pasternak , 2001 ; pertwee , 2001 for review ) . thus , it could be concluded that nociceptin - orll receptor and anandamide - cannabinoid receptor systems constitute an important part of endogenous antinociceptive system . however , cellular mechanisms underlying the actions of orl1 and cannabinoid receptors on nociceptive information transmission in the spinal cord are still unknown 行为学研究也观察到鞘内注入nociceptin和大麻受体的激动剂如win55 , 212 - 2 ( win - 2 ) 、 anandamide等均可在多种痛模型上(包括急性痛、持续性痛和慢性痛模型等)产生明显的抗伤害性作用( seemogil pasternak , 2001 ; pertwee , 2001forreview ) ，由此可见nociceptin ?孤啡肽受体系统和anandamide ?大麻受体系统构成了内源性镇痛系统的重要组成部分。
