Accordingly , the discovery of citrinin in monascus brought tremendous dispute about the safety of red starter products 红曲霉中桔霉素的发现使得我国的红曲产品的安全性引起争议。
2.
However , citrinin , produced in the growth process of monascus , is a mycotoxin and will induce teratogenicity , carcinogenicity and mutagencity 桔霉素是一种真菌毒素，作用的靶器官是肾脏，可以致畸、诱发肿瘤、突变等。
3.
The results showed that the content of citrinin and monacolin k from the hongqu samples produced by m12 were 0 . 11 ng / g , 213 , g / g respectively 同时，采用hplc对monacolink进行了分析测定， monacolink含量为213 g g 。将该样品对应的菌株编号为m12 。
4.
Through a series of mutagen tests , a mutant strain of monascus spp ( m 12 - 69 ) from ml2 was acquired , which can produce much higher monacolin k than m12 , and almost same citrinin level as m12 以之为出发菌株，通过诱变筛选，获得一株monacolink产率有明显提高而桔霉素产率仅为0 . 13ng g ( elisa )的突变株，编号为m12 - 69 。
5.
And the sample with the highest monacolin k content and its relative strains were acquired . the strain was numbered m12 . finally , monacolin k and citrinin in the sample above were precisely detected again by elisa and hplc respectively 以该方法对6个样品中的monacolink进行了分析测定，得到1个monacolink含量最高为225 g g ( dtlc )的红曲样品及其相应菌株。
6.
In this paper , the physical and chemical properties , the toxicological characteristics , the biosynthetic pathway and the detection method of citrinin produced in monascus were introduced and the relative counter measures to eliminate citrinin were also illustrated 介绍了红曲中产生的桔霉素的理化性质、毒性、产生途径和检测方法等的研究现状，并就如何消除红曲中桔霉素提出了对策。
7.
A single direction thin layer chromatography ( stlc ) was researched in order to detect citrinin from above samples , . the results revealed that ethyll acetate : toluene : formic acid ( 6 : 3 : 1 ) was a good developer , then the citrinin from the 29 hongqu samples above were detected , and 6 samples with citrinin less than 0 . 20 g / g ( stlc ) and their strains were screened 第二，以上述29个红曲样品为实验材料，对红曲中桔霉素的(单向)薄层层析( stlc )条件进行了研究。结果显示，以甲苯：乙酸乙酯：甲酸( 6 ： 3 ： 1 )为展开剂，桔霉素的分离效果较好。
