Study on the safety and immunogenicity of enterotoxigenic escherichia coli recombinant active vaccine 肠毒素大肠埃希菌载体活菌疫苗的安全性和免疫性研究
2.
Schubert et al reported that hpi was found in 93 % eaggec , 27 % enteroinvasive e . coli , 5 % enteropathogenic e . coli and enterotoxigenic e . coli 在不同类致泻性大肠杆菌中， hpi毒力岛在eaggec中高频分布的原因，目前也不清楚。
3.
Vibrio cholerae and enterotoxigenic escherichia coli ( etec ) are major pathogens that evoke acute diarrhea among children worldwide and travelers to developing countries 霍乱毒素与毒素大肠杆菌( etec )是引起婴幼儿和旅游者腹泻的主要病原菌。
4.
To dress the question if other virulence gene were present in this kind of strains , 152 of 436 irp2 - hybridized strains were re - confirmed and selected for this study . the virulence genes or putative virulence genes detected by pcr or hybridization include heat stable toxin ( st ) & heat labile toxin ( lt ) for enterotoxigenic e . coli ( etec ) , invasive plasmid antigen b ( ipab ) for enteroinvasive e . coli ( eiec ) , epec adherence factor ( eaf ) , epec secretion protein c ( espc ) for enteropathogenic e . coli ( epec ) , hemolysin ( hlya ) and shiga toxins ( sltl and slt2 ) for enterohaemorrhagic e . coli ( ehec ) and eaggec probe for entero - aggregative e . coli ( eaggec ) . the prra and yc73 genes of pathogenicity associated island ( pai ) of urepathogenic e . coli ( upec ) and " o " island 28 ( rtx 615 ) gene was also detected , the later was a newly discovered putative pathogenicity island in e . coli o157 : h7 为探讨携带小肠结肠炎耶尔森氏菌的hpi毒力岛的大肠杆菌是否具有其他已知的毒力基因，选取82株由原位杂交和pcr方法初筛irp2阳性的大肠杆菌菌株，进行在致泻性大肠杆菌的25个毒力基因的检测，包括肠产毒性大肠杆菌的热稳定毒素st和热不稳定毒素lt ，肠侵袭性大肠杆菌的侵袭蛋白b基因ipab ，肠致病性大肠杆菌的eaf 、 espc基因，肠出血性大肠杆菌的溶血素hly 、志贺毒素1 ( slt1 ) 、志贺毒素2 ( slt2 )基因，肠集聚性大肠杆菌的eaggec探针，以及在泌尿道致病性大肠杆菌和o157 ： h7大肠杆菌中新发现的毒力岛基因。
