| 1. | Effect of erk on 17 - estradiol - induced inhibition of vsmc proliferation in rats after vascular injury
雌二醇抑制大鼠血管损伤后平滑肌细胞增殖中的作用 |
| 2. | It is believed that erk mainly transduces growth promoting signals and the other two mainly tranduce growth inhibiting signals
现在认为erk1 2主要介导生长促进信号，而后两条途径主要介导生长抑制信号。 |
| 3. | 2 . the proapoptotic effects result from the reduction of erk , activation of jnk during treatment of bfgf and p38 also has some role in this process
Bfgf作用于u2 os细胞引起的erk活性抑制和jnk长时程激活共同介导了u2 os细胞凋亡的发生， p38也在一定程度上参与了这个过程。 |
| 4. | P - liquid scintillation counting was used for analysis of erk and immunocytochemistry was used for the analysis of c - jun . all the data were analyzed with statistical treatment . the results were showed as follows : 1
分别做p液闪计数观察erk的活性表达，做westernblot观察jnk的表达量变化，免疫组化观察cjun阳性信号的表达，并进行统计学处理，结果如下： 1 |
| 5. | Further analysis reveals that expression of ( - arrestin2 strengthened cxcr4 - mediated activation of both p38 mapk and erk and the suppression of ( - arrestin2 expression blocked the activation of two kinases
进一步的研究发现， - arrestin2可以增强cxcr4介导的erk及p38mapk的激活，但只有p38mapk的特异性抑制剂及显性失活突变体才可以阻断- arrestin2对趋化的增强作用。 |
| 6. | Interestingly , inhibition of p38 mapk activation ( but not erk activation ) by its inhibitors or by expression of a dominant negative mutant of p38 mapk could effectively block the chemotactic effect of ( - arrestin2
P38mapk上游激酶ask1的显性失活突变体也可以阻断- arrestin2对趋化的增强作用。这说明是p38mapk而不是erk信号通路与- arrestin2对趋化的增强作用相关。 |
| 7. | They are pkc , pka , mek1 in erk pathway , mekk1 in sapk / jnk , p38 in p38 pathway , the three latter pathways all belong to the map kiiiase pathway . the inhibition of pkc decreases the proliferation after the il - 16 treatments , which hint its role in proliferation signal transduction
结果表明，加入pkc的抑制剂，强烈抑制了所有浓度16处理下细胞的增殖，暗示pkc在u一16与cd4结合后，可能传递了增殖相关信号，它的存在是jllrk盯细胞的生长增殖必须的。 |
| 8. | Especially , at the site of implantation of day 5 , 6 , uterine stroma cell apposing the preimplantation blastocyst changed into the decidual cells and displayed a distinct immunostaining of phospho mapk . western - blot results showed p44 express stronger than p42 did , with both their peak expression were observed on day 5 , during the period of uterine decidualization
上述结果表明， ma卫k的激活与子宫内膜的接受性及蜕膜的形成有密切关系，推测mapk级联通路激活对蜕膜化十分重要，蜕膜化可能与egf尼gfr直接或间接激活erk有关。 |
| 9. | $ - liquid scintillation counting : erk basic activities had been found in the two control groups . the scores were 6582 . 38 ? 2605 . 70 and 6204 . 13 + 2212 . 40 . there had no obvious difference between them ( p > 0 . 05 ) . while erk activity was obviously lowered in the psd group which score was only 807 . 88 + 1326 . 76 . the expression of erk in psd group showed significant difference between the two control groups ( p < 0 . 05 )
Westernblot ：快目动睡眠剥夺组jnk （ c一junnhz上erminalkinase ）的表达量较两对照组均明显增加：与正常对照组相卜较增加了75 ；与快回动睡眠剥夺对照组相t较增加了62 |
