Weightlessness or simulated weightlessness has been shown to cause atrophy , to reduce contraction function , and to increase fatigability in rat hindlimb skeletal muscles 航天失重或模拟失重能够引起下肢肌肉特别是抗重力肌发生废用性萎缩，并使肌肉的收缩力降低，疲劳性增加。
2.
The increase in fatigability of high - frequency tetanic contraction in unloaded soleus ( sol ) may be related to the changes in sarcolemmal na + , k + , or l - type ca2 + channels and na + - k + atpase 模拟失重萎缩比目鱼肌( sol )高频强直收缩的疲劳性增加，其机理可能涉及肌纤维膜与t管na ~ + 、 k ~ +通道、 na - k泵和l型钙离子通道的功能的改变。
3.
6 ) increased fatigability of titanic contraction after 1 - wk unloaded soleus with high potassium perfusion with 10 mmol / l k + solution perfusion , there was no differenc in po between con and 1 week sus , but the p33 / po shown a significant increa 硝苯地平可抑制对照大鼠比目鱼肌mhcilamrna的表达，并可部分抑制萎缩比目鱼肌mhci向mhcila的转换，还可抑制mhcilb与ilxmrna的表达。
4.
With the development of space exploration projects , the atrophy and decreased function in antigravity skeletal muscles are one of major problems that need to be solved for the prolonged space flight . to understand the features of decreased contractile function and increased fatigability in unloaded hindlimb skeletal muscles will help to develop effective countermeasures during space flight , and contribute to the prevention and treatment of skeletal muscle atrophy in long - term bed - rest patients 随着载人航天活动的发展，航天飞行时间越来越长，抗重力肌废用性萎缩引起的强直收缩疲劳性增加，使航天员运动易疲劳的感觉更加明显，限制了飞行时间和工作效率，在应急逃生时肌肉发生损伤的可能性增大，且影响返回地面重力环境后的再适应能力。
