Proponents of the position that the shroud is authentic say that no known technique for hand - application of paint could apply a pigment with the necessary degree of control on such a nano - scale fibrillar surface plane 裹尸布可信度的支持者阵容声称没有可知的手工技术来涂颜料，而这种技术又是有必要的控制程度，例如在一块没有刻度的纤维表面上涂颜料。
2.
The propagation mechanism of the prion diseases is widely accepted that prpsc transforms prpc into the pathological form and more and more prpsc will gradually be produced and forms larger fibrillar aggregates . when a critical level of prpsc has accumulated , the neurons die , resulting in large vacuoles . the affected brain regions become sponge - like in appearance , hence the name spongiform encephalopathies to describe all prion diseases 目前普遍接受的朊蛋白疾病发生机制为prpsc转化prpc为致病形式，致使越来越多的致病蛋白形成并堆积成越来越大的纤维状聚集物，当致病蛋白聚集到一定程度，造成神经元死亡而使受累脑区呈现海绵样空洞，这也就是为什么用海绵样脑病来描述所有的肮蛋白疾病。
