| 1. | These include a pervasive feeling of sadness , disruption of sleep patterns including both insomnia and hypersomnia , disturbances in appetite and weight , listlessness , lack of interest ( leading to withdrawal from friends and social events ) , diminished ability in memory and concentration , low self - esteem and feelings of guilt , and finally , thoughts of suicide - the most serious symptom of all
症状包括长时间的情绪低落、睡眠不规律（包括失眠及睡眠过度） 、食欲不振及体重减轻、无精打采、缺乏兴趣（导致疏远朋友、回避社会活动） 、记忆力衰退、无法集中注意力、缺乏自信和负罪感，最终则会出现自杀的念头这是忧郁症最严重的症状。 |
