| 1. | Mirtazapine was prepared by a seven - step reaction , namely nucleophilic ring - opening reaction , chlorination , cyclization , uncleophilic substitution , hydrolysis , reduction and cyclization from styrene oxide and n - methylethanolamine as the starting materials , with overall yield of 22 . 6 %
摘要以环氧苯乙烯和n -甲基乙醇胺为起始原料，经亲核开环、氯代和环合反应得到中间体1 -甲基3 -苯基哌嗪。 |
