On the other hand , there is substanial evidences tha dcs mediate tolerane . the gm - csf - stbolated mouse bone mwderived mhc class ii + dc progendors tha are deficient in cell surface erpression of the costbolatory molecules b7 - l and b7 - 2 can induce alloanginspecific t ceil anergy in vbo . systendc adchstraion of these donor - derived dc progendors to recipients intravenously 7 days before transplantation prolonged the median graft survival tane from 9 . 5 days to 22 days wbout additional twnosuppressions in a mouse cardinc twlanation model 1995年， lul等报道表面缺乏共刺激分子，特别是缺乏cd80 ( b7 - 1 )和cd86 ( b7 - 2 )的未成熟型dc能在体外诱导同种抗原特异性的t细胞无能，而对dc的适当处理能够使未成熟型dc潜在的耐受原性得以放大和增强，使得dc在诱导免疫耐受中具有相当重要的作用及潜在的应用价值。
