English translation for "tnfa"

喷嘴总过流面积

Example Sentences:

	1.	Tnfa antagonists including mab against tnfa and tnf receptor ( tnfr ) , soluble tnfa receptor ( stnfr ) , mutant tnfa have been applied or tried to apply in the clinical with some positive therapy effects , but there were still some problems to limit the application of these agents 重组tnf及其拮抗剂(包括抗tnf单抗、抗tnf受体单抗、可溶性tnf受体、 tnf突变体)均已应用于临床并取得了一定的治疗效果。
	2.	We hope that our study will provide us with more comprehensive knowledge of the mechanisms of immune regulation and the roles that dc and complement play in innate and acquired immunity , as well as to lay a foundation for further exploration of the roles dc play in antigen - specific immune responses and immune tolerance from a new perspective . part i expression of complement receptors and complement - associated molecules on dendritic cells derived from distinct - origin at different stages of development two subsets of dendritic cells were generated from precursor cells isolated by means of magnetic cell separation system 曰补体受体及其相关分子在modc上的表达不同分化阶段的单核细胞衍生性dc ( monocytes一deriveddc ， modc )的诱导:将新鲜分离的单核细胞mo ，在含有gm一csf和工l一4培养体系中诱导5一7d ，即分化为未成熟modc ;对培养至sd的未成熟modc ，用tnfa刺激zd ，即分化为成熟modc ;此时再用lps刺激24h ，即为活化的modc 。
	3.	After 3 rounds of screening , 10 of 20 clones were identified as positive clones and all the 10 phage clones sharing the same amino acid sequence : ehmaltypfrpp , and these positive 12mer phage clone peptide can bind with tnfa specifically . the results suggests that this method is very specific and simple for screening of binding epitope to small peptide molecule from phage display peptide library 在以噬菌体环七肽tnfa模拟肽克隆刁k naqsoc ）为靶对噬菌体随机十二肽库进行h轮筛选后，挑取20个克隆，经elisa鉴定有10个克隆均与t ’ nfa结合，测序结果显示它们均为同一氨基酸序列： ehmaltypfrpp 。
	4.	Part iv computer - aided molecule modelling of tnfa mimotopes and tnfa - binding peptides : to investigate the interaction between tnfa mimotopes and tnfa - binding peptides , the computational docking program autodock ( with confirming calculations using discover ) was used to predict the binding modes of llt - 18 with tnfa firstly , then lcs - 7 was docked to llt - 18 by manual . the interaction between llt - 18 and tnfa or lcs - 7 showed electrostatic interaction and h - bond dominant 进行对接，对两者间结合位点进行分析；在此基础之上，以insight11软件构建lcs刁分于三维结构， autodock程序对接llt和lcs 7两个短肽分子，找寻两者结合的关键性残基，结果表明llt与tnfa及lcs 7分子间相互作用以静电相互作用为主， lcs刀和tnfa活性部位的arg在分于间相互作用中起重要作用。
	5.	Part ii screening of tnfa mimotopes from phage display peptide library : based on the results of screening tnfa binding - peptides , we have tried to use neutral tnfa mcab j1d9 as target to screen tnfa mimotopes from c7c phage display peptide library , which may be another form of antagonist for tnfa , and the mimotopes were identified by sandwich elisa . after 3 rounds of screening , we got 9 phage clones identified as positive clones which can bind with mcab j1d9 . we also identified the binding between mimotopes and tnf receptor by competitive elisa , and the results showed strongly binding . the amino acid sequence results shown three different sequences : c - rrpaqsg - c - nkhnrki - c and c - rgmsrki - c 在对噬菌体环七肽库进行三轮亲和性筛选后，随机挑选20个噬菌体克隆， elisa鉴定出9个阳性克隆，经dna测序推出三种氨基酸序列： c - rrpaqsg - c 、 c - nkhnrki - c和c - rgmsrki - c ，其中优势克隆序列为c - rrpaqsg - c ；鉴定结果显示阳性克隆能够与tnf受体结合，并且能够阻断tnf与受体的结合，提示筛选得到的环七肽克隆展示肽具有tnf的抗原性及与tnf受体结第一军医大学顾士学位论文合的特性，为tnfa表位模拟肽。
	6.	Recently , some new studies suggest that small cytokine peptide - mimics can function as the agonist or antagonist of cytokine receptor , and these small molecular peptides can be synthesized easily and oral adminstration with high concentration . based on these work , we have tried to set up experiment on tnfa - binding peptides and tnfa mimotopes which may be as leads of tnfa antagonist 近年来的研究发现，小分子细胞因子模拟物具有细胞因子受体激动剂或拮抗剂的作用，且小分子模拟物因容易合成并能够给予高浓度、可口服等优点使其具有更加广阔的研发与应用前景。
	7.	Our research can be divided into the following four parts : part i screening of tnfa - binding peptide from phage display peptide library : the tnfa binding - peptides were screened from c7c phage display peptide library by using rhtnfa as target protein and identified by sandwich elisa , for exploring whether the binding - peptides can be used as antagonist of tnfa or not 筛选tnf小分子模拟肽及结合肽对于tnf研究具有重要的意义。本研究包括以下四个方面： 1 、 tnf结合肽的研究：以rhtnf为靶对噬菌体环七肽库进行筛选，以寻求可拮抗tnf活性的小分子短肽。
	8.	These phage display peptides may be the tnfa mimotopes . part iii specific c7c tnfa mimotope phage clone as target for screening of tnfa specific binding - peptides from 12mer phage display peptide library : by using the specific c7c tnfa mimotope as target , we developed a novel approach for screening phage peptide library targeting specific phage display peptides . we used c7c tnfa mimotope phage clone lcs - 7 ( c - rrpaqsg - c ) as target to screen 12mer phage peptide library and identify the positive clones by phage elisa 3 、以特异性噬菌体克隆为靶筛选肽库的研究? ?一种肽库筛选新方法的建立：为了深入研究细胞因于与配基（受体或抗体）相互作用的关键残基及其空间构象，在上述研究基础上，我们以tnfa表位模拟肽克隆为靶筛选噬菌体十二肽库，找寻与之结合的tnfa结合肽噬菌体克隆；并以此拓宽了噬菌体肽库的应用范围。
	9.	It is well known that tumor necrosis factor a ( tnfa ) can play very different character in defence mechnism of body and pathologic injury , in which it can inhibit or kill tumor cell , and induce inflammation against infection ; on the other hand , tnfa can be as a very important mediator to cause some serious pathologic processes such as septic shock , gvhr and some autoimmune diseases 肿瘤坏死因子( tumornecrosisfactor ， tnf )具有对某些恶性肿瘤的抑制或杀伤作用，也是致内毒素性休克、急性移植物抗宿主病及一些自身免疫病的重要效应因子，因此tnf的改造和tnf拮抗剂的研究受到各国学者的重视。

Similar Words：

"tnf tumor necrosis factor" English translation, "tnf-bp" English translation, "tnf-inhibitory factor" English translation, "tnf-lt blocking factor" English translation, "tnf-淋巴毒素阻断因子" English translation, "tnfbf" English translation, "tnf结合蛋白" English translation, "tnf抑制因子" English translation, "tng" English translation, "tng 3x05the bonding" English translation