| 1. | Fold recongition and structure simulation for the ricin - like domain of human polypeptide : n - acetylgalactosaminyltransferase
乙酰氨基半乳糖转移酶2蓖麻蛋白样结构域的折叠识别和结构模拟 |
| 2. | Cloning of the genomic fragments of bovine 1 , 3 - galactosyltransferase gene and construction of a promotorless targeting vector
半乳糖转移酶基因部分片段的克隆及无启动子打靶载体的构建 |
| 3. | The results show that , ( 1 ) in different human tumor cells , n - acetylgalactosaminyltransferases gene expression levels differ from each other
这表明： (一)在不同肿瘤细胞中， n -乙酰氨基半乳糖转移酶基因的表达水平不一。 |
| 4. | But the ppl researchers have succeeded in knocking out only one copy of the gene for the enzyme , called alpha 1 ， 3 galactosyl transferase
但是, ppl医疗公司的研究人员只是成功地去除了产生这种叫? 1 , 3半乳糖转移酶的基因的一个副本。 |
| 5. | Objective to analyze the differences of n - acetylgalactosaminyltransferases gene expression profile in different human tumor cells with preliminarily made cdna microarrays
目的本研究初步创建了低密度基因芯片，并对人不同肿瘤细胞中的n -乙酰氨基半乳糖转移酶基因家族进行表达谱分析。 |
| 6. | At the same time , it also preliminarily proves that there is a certain relation between n - acetylgalactosaminyltransferases gene expression levels and tumor formation , which necessitates more detailed studies
同时也初步证明： n -乙酰氨基半乳糖转移酶基因家族表达和肿瘤的发生有着一定的相关性，但它们之间具体的联系还需进一步的研究。 |
| 7. | ( 2 ) in the same tumor cells , each n - acetylgalactosaminyltransferases gene which differs in expression levels , displays noticeabl e differences from those in normal cells . conclusion n - acetylgalactosaminyltransferases genes have different expression profiles in different tumor cells
(二)在同一肿瘤细胞中， n -乙酰氨基半乳糖转移酶基因家族各个成员的表达也有差异，而且与正常细胞中n -乙酰氨基半乳糖转移酶基因家族的表达显著不同。 |
| 8. | Results n - acetylgalactosaminyltransferases cdna library has been made successfully for the creation of low - density microarrays for gene expression profiling , with which , the different positive signals of n - acetylgalactosaminyltransferases gene expression can be observed in human tumor cells through chemiluminescent detection
通过此芯片采用化学发光法能够检测到人肿瘤细胞中的n -乙酰氨基半乳糖转移酶基因家族不同程度的阳性信号。 |
| 9. | Although the development of relatively non - toxic immunosuppressive or tolerance - inducing regimens will be required to justify clinical trials using pig organs , recent advances in our understanding of the biology of xenograft rejection and zoonotic infections , and the generation of alpha1 , 3 - galactosyltransferase - deficient pigs have moved this approach closer to clinical application
尽管用猪的器官进行临床试验尚有赖于相对无毒的免疫抑制剂或致耐方法的发展，但是我们在异种移植排斥反应及猪源人畜共患病等方面生物学知识的进步，以及1 ， 3半乳糖转移酶缺陷猪的产生，已经使异种移植离临床应用更近了一步。 |
| 10. | Although the deelopment of relatiely non - toxic immunosuppressie or tolerance - inducing regimens will be required to justify clinical trials using pig organs , recent adances in our understanding of the biology of xenograft rejection and zoonotic infections , and the generation of alpha1 , 3 - galactosyltransferase - deficient pigs hae moed this approach closer to clinical application
尽管用猪的器官去验证临床试验需要相对无毒的免疫抑制剂或致耐的方法，但随着近来我们对异种移植排斥生物学及动物传染病感染的深入理解，以及1 ， 3半乳糖转移酶缺陷猪的产生，异种移植更接近临床应用。 |
