| 1. | A signal transduction via not only two - component regulatory system but also serine / threonine kinases generally regulates morphological and physiological differentiation in streptomyces
途经双元件调控系统和丝氨酸苏氨酸蛋白激酶的信号传导调控链霉菌的形态和生理分化。 |
| 2. | The vfcpkl has an obvious kinase catalytic domain for ca2 + / calmodulin dependent protein kinases and serine / threonine protein kinases , and a calcium - binding domain like calmodulin
Vfcpk1具有明显的ca ~ ( 2 + )钙调素依赖蛋白激酶及丝氨酸苏氨酸蛋白激酶的激酶区以及类似于钙调素的钙结合区。 |
| 3. | The kinase catalytic domain is 264 amino acids in length and contains all of 11 conserved subdomains and 15 invariant amino acid residues essential fo r eukaryotic serine / threonine protein kinases
激酶区长264个氨基酸残基，具有所有11个保守的亚结构域和15个对于真核生物丝氨酸苏氨酸蛋白激酶所必需的保守的氨基酸残基。 |
| 4. | The term protein kinase c ( pkc ) stands for a group of at least twelve serine / threconine kinases that are characterized by a high degree of similarity in their catalytic kinase domains and cysteine - rich regions
前言蛋白激酶c ( pkc )是一组丝苏氨酸蛋白激酶，参与多种信号传导系统。包括细胞分化、生长调控、肿瘤发生和细胞凋亡。 |
| 5. | Mpf ( m phase promoting factor ) which is made up of cdc2 as the active subunit and cyclin b as the regular subunit is a key factor in cell division . cdc2 is the active part of the mpf , which can active multiple ser / thr
Mpf ( mphasepromotingfactor )是细胞分裂的中心调控因子，由催化亚基cdc2和调节亚基周期素b ( cyclinb )组成，其中cdc2是mpf的活性单位，具有丝苏氨酸蛋白激酶活性。 |
| 6. | Many cell signal transduction pathways have been discovered in the regulation of apoptotic induction and reduction . mito - gen - activated protein kinase ( mapk ) is a group of particular ser / thr protein kinases which are activated when its conservative thr and tyr residues are both phosphorylated by upstream mapk kinases
丝裂原活化蛋白激酶( mapk )是一群特殊的丝苏氨酸蛋白激酶，它通过其上游mapkk使其保守的苏氨酸和酪氨酸残基双磷酸化而活化，活化的mapk可转移到核内，参与基因表达调控。 |
| 7. | The mouse fertilized egg is the most simple and natural mammalian model of cell cycle , there are few reports about the mechanism on the regulation of early development of mouse fertilized eggs especially the events of entry into m - phase . its the first time we report here that pkb exists and effects on g2 / m phase transition in mouse one - cell stage fertilized eggs
148 - 411是激酶区(催化域) ，和其它丝苏氨酸蛋白激酶有较高的同源性，其中有一个保守的thr ，它位于308 、 309或305位；从412位起为c末端尾区(调节域) ，除pkb -外都有一个保守的ser ，位于473或474位。 |
| 8. | Protein kinase b is newly found as a serine / threonine protein kinase , it could have widely spread functions in cell cycle regulation . the activation of protein kinase b / akt is thought to be a critical step in the phosphoinositide 3 - kinase pathway which regulates cell growth and differentiation
蛋白激酶c ( proteinkinasec ， pkc )和蛋白激酶b ( proteinkinaseb ， pkb )同属于丝苏氨酸蛋白激酶，广泛参与细胞的多种生命过程，包括生长、分化、细胞周期调控、细胞凋亡等。 |
| 9. | Protein kinase a is camp - dependent kinase , one of the most important signal transduction pathways , plays a pivotal role in growth , differentiation , tumor occur , cell cycle control , etc . pka activators such as camp , 8 - br - camp or phosphodiesterase ( pde ) inhibitor isomethyl butyl xanthine ( imbx ) or purified pka catalytic subunit all can inhibit germinal vesicle breakdown ( gvbd ) and meiotic maturation in mouse oocytes , also in xenopus oocytes
蛋白激酶a ( proteinkinasea ， pka )是依赖于camp的丝苏氨酸蛋白激酶，是重要的信号传导途径之一，广泛参与许多生命过程，包括生长、分化、肿瘤发生、细胞凋亡、细胞周期调控等。以小鼠卵母细胞为实验对象，给予pka激动剂camp 、 8 - br - camp或磷酸二酯酶抑制剂imbx ( isomethylbutylxanthine )均可抑制小鼠卵母细胞的胚泡破裂及减数分裂成熟。 |
