The best bet at the moment is probably that the phage integrase method can be used by getting a better hold of how its site - specificity works and therefore being able to design changes to it rather than using the very weak technique of in vitro evolution - - but this will need a lot of hard work 目前大可一赌的是：嗜菌体整合酶方法也许可以利用：较好地拿捏位点特异性使之起作用，而因此能设计改变嗜菌体整合酶，而不是利用体外进化的很不可靠的技术?但这需要做大量艰苦的工作。
