To study the effect of the hemodynamic factors on the atherogenesis , a series of spatial 3d asymmetric geometric models of coronary artery were built up in this paper 调查结果表明,发达国家中大约有百分之五十五的人在年轻时冠状动脉中就已开始出现脂肪纹和纤维斑,这是心血管疾病的最初表现。
2.
These results indicate that endothelial gap junctions are highly involved in atherogenesis and suggest that down - regulation of endothelial gap junction may be used as a marker of endothelial dysfunction 这些结果说明内皮缝隙连接与动脉粥样硬化的发生高度相关,提示我们可以把内皮缝隙连接下调作为内皮功能障碍的一个标志。
3.
Although there is no association of their metabolism , their parallellic abnormality in dicates that some possible factors changing in diabetics can influence the metabolic pathway of both lipid and uric acid which may promote each other for atherogenesis in diabetics 虽然二者没有明显相关性,但在糖尿病患中,二者平行的现象,表示可能有一些在糖尿病改变的因素能够同时改善脂肪及尿酸之代谢,诞改变可以互相促进糖尿病患的血管硬化。
4.
This study on the accelerated atherogenesis in obese children is the first of its kind , and the results of this innovative project will be presented at the coming 50th annual congress of the american college of cardiology to be held in march 2001 at orlando of usa 世界文献目前为止还未有任何有关儿童肥胖可引致加速性动脉粥样硬化病变的报告,而中大这项研究结果部份将会在本年三月召开的第五十届全美心血管专科学院年会上率先发表。
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" traditional chinese diet which emphasizes vegetables , plant protein , rice and green tea , but less dairy product , meat , and deep fried food , is protective against atherogenesis , " as reported by professor woo earlier this month at the american heart associations scientific session in atlanta , usa , which has received worldwide recognition 胡教授较早时出席美国心脏学会于亚特兰大举行的科学会议上指出:传统华人饮食注重蔬菜、植物蛋白质、米饭及绿茶,而较少有奶制品、肉类及油炸物,相信能有效预防动脉粥样硬化。
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Deficiency of apoe may promote to produce and develop atherosclerotic lessions . the apoe gene - targeted mice will result in marked regression of both early and advanced atherosclerotic lesions by injected apoe recombinant protein , or by transfected adviral vector with apoe cdna to express human apoe transgene in liver , or by transplantation of bone marrow with normal rat apoe gene . this demonstrates that apoe gene and its expressing product can inhibit progression of atherogenesis . apoe3 has a more effective prevention from as than apoe2 and apoe4 Apoe的缺失可促进动脉粥样硬化的发生发展,给apoe基因敲除鼠反复注射apoe重组蛋白、在肝组织中用腺病毒载体表达apoe蛋白、移植带有正常apoe基因的小鼠骨髓,都能使apoe基因敲除鼠的动脉粥样硬化得到回复,表明apoe基因及其表达产物对动脉粥样硬化的发生具有抑制作用, apoe _ 3对动脉硬化的阻抑作用要比apoe _ 2和apoe _ 4都明显。
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There is more and more evidence that hemodynamic factors play an important role in the development of the arterial atherogenesis , but even up to now , the specific role of the hemodynamic factors is not well understood yet , therefore further research work of revealing the biomechanical mechanism of atherosclerosis is helpful and necessary to learn its pathology and occurrence , which is very important in biofluid dynamics and is closely related to the development of the biofluid dynamics in theory and numerical simulation , the investigation of coronary circulation rules of human cardiovascular system and the further study of occurrence mechanism of cardiovascular diseases , so is of great significance in both scientific research work and realistic application 越来越多的研究证据表明,血流动力学因素在动脉粥样硬化的发生和发展过程中起着关键的作用。但时至今日血流动力学因素确切的作用还需要进一步了解,因此更深入地研究动脉粥样硬化的生物力学机理对于掌握动脉粥样硬化的病理和发病规律有着巨大的研究价值。近年来,随着人们生活水平的不断提高和生活结构的逐步改变,心血管病的发病率也在不断增加,并已经成为危害人类生命健康最为严重的疾病之一,其患病率和死亡率居各类疾病之首,因而成为发达国家和发展中国家的头号杀手。
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" to date , there are few similar studies documenting such accelerated atherogenesis in obese children so far , and this innovative project by cuhk clearly indicates that overweight or obesity in children may cause various impairment of endothelial function . " professor woo elaborated . " this may lead to cardiovascular disease or other metabolic diseases when the child grows up 到目前为止,甚少文献报道有关儿童肥胖可引致加速性动脉粥样硬化病变的报告,而中大这项研究结果的公开发表,则清楚显示在儿童时期,超重或肥胖可能导致动脉血管内皮功能发生不同程度的障碍,随著年龄的增长,更可引起一系列心血管疾病和其他代谢性疾病。