Increasing evidence indicated that peripheral iglurs play an important role in the process of activation of nociceptors . recently , bhave et al . showed that group i mglurs , including mglur1 and mglur5 , are also located in terminals of primary afferent fibers by morphological examinations 本研究采用行为学和功能形态学的方法( formalin引起的fos表达) ，试图从功能上证实分布在初级传入神经元外周轴突上的mglurs参与伤害感受器的激活，在外周痛信号的产生中发挥重要作用。
