Histopathological examination revealed that most of the ulcer were re - epithelialization in the large and moderate doses groups , but in negative control group , most of the ulcer were not healed at the 14th day after operation 结果：在伤后14天内，复方壳聚糖膜剂外贴可使溃疡面积和容积缩小的速度及表皮完全覆盖率均高于空白对照组。
2.
It is well known that various kinds of biological substances such as growth factors , cytokines and adhesion molecules are closely related with the wound healing process . in particular , adhesion molecules play an important role in the promotion of inflammatory reaction , these factors stimulate the synthesis of extracellular matrix by local fibroblasts , generate new blood vessels , promote the granulation tissue fonnation , and enhance re - epithelialization nthat takes places by the migration of the kerati - nocytes from the edges of the wound toward the center 多种生物学介质如：生长因子、细胞因子及粘附分子等与皮肤损伤愈合过程密切相关，尤为值得提出的是，粘附分子在炎症的发生的起始过程中起着至关重要的作用，这些因子在细胞外基质的形成、血管的发生、肉芽组织的生成及上皮的再形成方面等均具有重要作用。
