| 1. | Hydroxychloroquine is a recognized therapy for patients with pss
羟氯喹被公认用于干燥综合征患者。 |
| 2. | Hydroxychloroquine is known to hae marked pharmacokinetic ariability [ 45 ]
已知羟氯喹有明显的药动学可变性45 。 |
| 3. | In addition , we hae speculated on a new mechanism for the action of hydroxychloroquine leading to an improement in saliary flow rate
另外，我们推测了羟氯喹的一种新作用机制，升高唾液流速。 |
| 4. | In addition , the transition of hyperthyroidism to hypothyroidism occurred in the medication of sle with steroids and hydroxychloroquine
而甲状腺功能由亢进转变为低下发生在治疗全身性红斑狼疮而使用类固醇及氢氧奎宁的时候。 |
| 5. | Further work is needed to explore this possibility and we intend to determine the in io effect of hydroxychloroquine on saliary cholinesterase following 6 months of therapy
进一步的探索工作是必须的，我们试图测定6个月治疗后羟氯喹对唾液胆碱酯酶体内方面的作用。 |
| 6. | Putting together , we suggest that corticosteroids and hydroxychloroquine for treating sle activity are able to control thyroid inflammation and hypothyroid function
总之，治疗全身性红斑狼疮而使用的皮质类固醇及氢氧奎宁可能可帮助控制甲状腺发炎及甲状腺功能低下症。 |
| 7. | In case , we noticed that corticosteroids or hydroxychloroquine may help to control autoimmune thyroid inflammation in sle patients with hypothyroidism , and may turn abnormal thyroid function back to normal
在第一个病例中，我们注意到皮质类固醇或氢氧奎宁可能可帮助全身性红斑狼疮合并甲状腺功能低下症的病人控制自体免疫性甲状腺发炎及将不正常的甲状腺功能转变为正常。 |
| 8. | Taken together , these findings indicate that further work is needed to re - ealuate the use of hydroxychloroquine in the treatment of pss and that increased leels of saliary cholinesterase actiity could proe to be a useful marker to indicate those patients who would show an improement in their saliary flow rates if placed on hydroxychloroquine
这些所有的发现表明了进一步的研究是必须的，重新评价羟氯喹在治疗原发性干燥综合征中的作用，以及唾液胆碱酯酶水平增加能证明作为一个有用的指标，以确认患者使用羟氯喹后唾液流速得到改善。 |
| 9. | It is tempting to speculate that the high degree of ariability in the steady - state pharmacokinetics of hydroxychloroquine may explain why inconsistency in clinical improement is found in patients with pss taking hydroxychloroquine , as it is possible that only those patients who hae both a high glandular cholinesterase actiity and achiee high blood concentrations of hydroxychloroquine show improement in saliary flow [ 12 , 14 ]
这是个具有吸引力的推测，稳态药动学中羟氯喹的高可变性能解释为什么使用羟氯喹的患者临床的改善不一致，同样有可能，仅仅那些既具有高水平的唾液胆碱酯酶活性有具有高的羟氯喹血药浓度的患者才显示唾液流量的升高12 ， 14 。 |
