Upregulation of neurod mrna expression might underlie elf - emf effect on promoting mesencephalic progenitors to a neuronal phenotype Emfs的促神经前体细胞神经元向分化的效应与其在转录水平上调neurodmrna的效应有关。
2.
In addition , the immediate elf - emf exposure might induce cell cycle arrest , thus also contributing to its stimulating effect of neurogenesis from mesencephalic neural progenitors 此外， elf emfs抑制中脑神经前体细胞增殖，加速神经前体细胞退出细胞分裂周期，可能也是elf
3.
Our previous studies confirmed that the central pathway of trigeminal proprioceptive sensation consists of four orders of neurons , and neurons from the first - to the fourth - order are located , respectively , in the mesencephalic trigeminal nucleus ( vme ) , the dorsomedial part of the subnucleus oralis of the spinal trigeminal nucleus and its adjacent reticular formation ( vodm - lrf ) , the " zone - shaped area " [ including the caudolateral part of the supratrigeminal nucleus ( vsup - cl ) , the dorsomedial part of the principal sensory trigeminal nucleus ( vpdm ) , the area ventral to the motor trigeminal nucleus ( avm ) and the area dorsal to the superior olivary nucleus ( ado ) ] and the contralateral ventral posteromedial nucleus ( vpm ) of the thalamus . because the pathway is a novel one , there has been little systematic morphological data available so far regarding the neurotransmitters involved in this pathway 该通路中第二、三级神经元所在地分别是三叉神经脊束核吻侧亚核背内侧区及其邻接的网状结构( dorsomedialpartofthesubnucleusoralisofthespinaltrigeminalnucleusanditsadjacentreticularformation ， vodm - lrf )和带状区[包括背侧的三叉上核尾外侧部( caudolateralpartofthesupratrigeminalnucleus ， vsup - cl )和感觉主核背内侧部( dorsomedialpartoftheprincipalsensorytrigeminalnucleus ， vpdm )及腹侧的两个分别位于三叉神经运动核腹侧和上橄榄核背侧的暂命名为avm ( areaventraltothemotortrigeminalnucleus )和ado ( areadorsaltothesuperiorolivarynucleus )的两个小核团] 。
4.
Only il - 1 could be used to predispose mesencephalic neural progenitors to enrich cell yield in a neuronal phenotype before cell transplantation . ( 2 ) the effects of cntf and il - 1 on neural progenitor differentiation were dose - related . ( 3 ) coeffects of elf - emf and cytokines were neither synergized nor antagonized , implying a potential role of organism emf during cns development 显示emf与cntf 、 il一1a的共同效应不是简单的胁同或拮抗，提示emf可能与细胞因子共同影u向应着神经系统的发育。
5.
The elf - emfs had no impact on neurite outgrowth . it was concluded that elf - emf , with the advantage of economy , convenience , as well as easy control , might be an effective method ex vivo to manipulate neural progenitors differentiation in stem - cell therapy . the possible mechanism of the elf - emfs effects on neurogenesis of mesencephalic progenitors was further explored Emfs的此效应具有频率特异性，场强也是影响因素； 10 20 40hz ( 8mt ) emfs还可增加衍生于中脑神经前体细胞的th阳性细胞数；但各频率emf对神经突的延伸均无作用。
6.
By the analysis of cell cycle disturbution and the examination of mashl , neurod and notchl mrna expression in proliferating or differentiating neural progenitors , the findings implied an important role of neurod in controlling the neuronal fate commitment in mesencephalic neural progenitors from newborn rats 增殖及分化期的新生大鼠中脑神经前体细胞neurod 、中义摘要mashl和notchl基因表达的测定结果表明， neurod基因在新生大鼠中脑神经前体细胞神经元向分化中发挥关键作用。
7.
The result indicated that the nadph - dstained neurons and fibers were found in discrete regions throughout the snake brain , such as cerebral hemisphere , supraoptic nucleus , paraventricular nucleus , subcommissural organ , medial longitudinal fasciculus , periventricular grey , locus coeruleus and mesencephalic reticular formation 结果表明：阳性反应主要位于脑的大脑半球、视上核、室旁核、联合下器官、内侧纵束、室旁灰质、蓝斑以及网状结构等区域，比较讨论了与其他脊椎动物的异同。
8.
In the subsequently serial differentiation studies , the findings were as followed : ( l ) among observed chemicals , only 50 pg / ml il - 1 was found to promote neuron - oriented differentiation of mesencephalic neural progenitors while 100 ng / ml gdnf , 10 ng / ml cntf and 10 - 5 mm gastrodin indicated a inhibitory effect , the rest chemicals , 10 - 5mm puerarin , or 10 - 5mm arctiin , or 10 - 5mm ginsenoside rgl , had no effect on neuronal differentiation . these findings confirmed that fate decision of newborn rat mesencephalic progenitors could be manipulated by environmental signals 施加elf emf ( 5hz 8mt )后，小剂量cntf的促进效应增强，特别是emf还可使大剂量cntf抑制神经元向分化的效应转变为促进神经元向分化； emf可抑制小剂量il一1q促进神经元分化的作用，但不影响大剂量il ? lq的诱导结果。
