Oncogenic mutations initiate tumorigenesis , but angiogenesis is necessary for expansion of tumor mass 癌基因突变引起肿瘤形成，而血管生成则是肿瘤扩大所必需的。
2.
In addition to accumulating and preserving these oncogenic scars , a stem cell ' s enormous proliferative capacity makes it an ideal target for malignancy 干细胞除了可累积并保存这些致癌突变外，还具有强大的增殖能力，使它成为癌化的理想目标。
3.
The programme focuses on studies in the molecular pathogenesis of influenza , emerging bacterial and fungal infections and antimicrobial resistance , and oncogenic viruses 计划的研究焦点分别在流感的分子性致病源、新发细菌及真菌感染、抗微生物耐药性及致癌性病毒。
4.
Transformed , oncogenic precursors , possessing both defining neural - stem - cell properties and the ability to initiate intracerebral tumours , have been identified in human brain cancers 人类脑部肿瘤中已经证实，突变的致瘤前体细胞不仅具有神经干细胞性能并且能致脑部肿瘤发生的潜能。
5.
Here we will discuss how cell fusion can link viruses to cancer , what types of cancers it can affect , how the existence of this link can be tested and how the hypotheses that we propose might affect the search for human oncogenic viruses 这里我们将探讨细胞融合是如何来为病毒与癌症之间搭建桥梁，什么类型的癌症可以感染，这一桥梁的存在是怎样被检测和我们提出的这一假说如何可能影响对人致癌病毒的查找等诸多问题。
6.
The env protein deduced from env gene encodes the hydrophilic surface protein ( su ) and the hydrophobic transmembrane domain ( tm ) that determine the specific interaction between virus particles and cell surface receptors during retroviral entry . the su of retroviruses is a highly variable genetic element , containing receptor binding sites and major antigenic determinants . exjsrv - specific dna probes were derived . by using these dna probes in tissue hybridization . we successfully identified jsrv mrna expression and proviruses dna in sheep lung tissues infected with jsrv and control group has no postive signals , validating the use of exogenous virus - specific dna probes in the analysis of oncogenic proviral integration sites and identification of integrated exogenous proviral sequences 用地高辛随机引物法标记exjsrv特异的env片段，制备探针，原位杂交检测spa肺组织中的rna及前病毒dna ，结果表明spa患羊肺组织内有jsrvenv基因mrna的表达，同时也检测到了前病毒dna ，而相应的阴性对照却无阳性信号，证实外源性病毒特异的dna探针在致瘤性前病毒的整合位点和整合的外源性前病毒的检测中具有可信度。
7.
Four mcabs were developed and can detect the meq gene expression in the cef infected with oncogenic mdvs and naturally occurred md tumor cells by fa and immunohistochemistry technique respectively , but ca n ' t detect that in the cef and normal chicken liver tissue respectively infected with non - virulent vaccine virus cvi988 / rispens . the results demonstrated that meq is highly expressed in t 获得4株稳定产生抗meq蛋白mcab的杂交瘤细胞，其中3g12e6单抗通过fa和免疫酶组化技术能够检测到mdv致瘤株感染的cef及自然md肿瘤细胞中表达的me叮基因产物，而在非致瘤株cvi988 / rispens感染的cef和免疫的正常鸡的组织中则未检测到。
