Standard test method for oncogenicity study in rats and mice 老鼠和小家鼠致瘤性研究的标准试验方法
2.
Pp38 was found to have immunosuppressive effect on chicken in vivo and the copy number of 132 - bpr was found to be associated with the attenuation of the virus in vitro , meq was believed to be a potential oncogene , based on its leucine zipper structure and proline - rich domain characteristic of jun / fos family of transcription factors , and may plays an important role in the pathogenicity or oncogenicity of mdv 其中， meq与132 - bpr两个基因是mdv - 1所特有，已证实132 - bpr的拷贝数与毒株的体外致弱程度有关， pp38则被证实可抑制机体的免疫应答。 meq基因由于具有与致瘤基因jun fos家族类似的分子结构，因此，我们有理由认为meq基因在mdv致病、致瘤中可能发挥重要的作用。
