To establish an animal model simulating nasal allergy in human beings , guinea pigs were actively sensitized with ovalbumin by nasal stimulation and or intraperitoneal injection 摘要为了建立一个动物实验模式来模拟人类鼻过敏症以便对鼻过敏症之发生机转做更深入的探讨，从而对治疗方法有所研发，我们利用天竺鼠为实验对象进行实验。
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Methods 50 wistar rats were sensitized by ovalbumin as animal model of ar and randomly divided into 5 groups : model group , ketotifen fumarate group , xinqin granules group , low - dose minkang tablet group , and high - dose minkang tablet group , another 10 healthy rats in normal group 方法除正常组外，其余大鼠用卵清蛋白造成变应性鼻炎模型，随机分为模型组、西药对照组（酮替芬组） 、中药对照组（辛芩冲剂组） 、敏康片小剂量组、敏康片大剂量组；用药1周后观察大鼠一般情况及鼻黏膜肥大细胞数、脱颗粒细胞数、血浆组胺的变化。
