Protein kinase a is camp - dependent kinase , one of the most important signal transduction pathways , plays a pivotal role in growth , differentiation , tumor occur , cell cycle control , etc . pka activators such as camp , 8 - br - camp or phosphodiesterase ( pde ) inhibitor isomethyl butyl xanthine ( imbx ) or purified pka catalytic subunit all can inhibit germinal vesicle breakdown ( gvbd ) and meiotic maturation in mouse oocytes , also in xenopus oocytes 蛋白激酶a ( proteinkinasea ， pka )是依赖于camp的丝苏氨酸蛋白激酶，是重要的信号传导途径之一，广泛参与许多生命过程，包括生长、分化、肿瘤发生、细胞凋亡、细胞周期调控等。以小鼠卵母细胞为实验对象，给予pka激动剂camp 、 8 - br - camp或磷酸二酯酶抑制剂imbx ( isomethylbutylxanthine )均可抑制小鼠卵母细胞的胚泡破裂及减数分裂成熟。
2.
" the concept is that systemic sclerosis , which is a severe disease characterized by systemic fibrosis , is at the beginning mainly a vascular disease , and we hypothesize that using major vascular drugs ( calcium channel blockers , endothelin antagonists , prostacyclins , phosphodiesterase inhibitors , etc . ) from the beginning and at appropriate dosage may interfere with the fibrotic process which seems secondary , " dr “从概念上讲，系统性硬化是一种以系统性的纤维化变性为特征的严重疾病，早期主要表现在血管性的病变，因此我们推测早期、适量地应用主要作用于血管的药物（如钙离子阻断剂，内皮素拮抗剂，前列环素，磷酸二酯酶抑制剂等）可能可以干预似乎是继发发生的纤维化过程。 ”
3.
" the concept is that systemic sclerosis , which is a seere disease characterized by systemic fibrosis , is at the beginning mainly a ascular disease , and we hypothesize that using major ascular drugs ( calcium channel blockers , endothelin antagonists , prostacyclins , phosphodiesterase inhibitors , etc . ) from the beginning and at appropriate dosage may interfere with the fibrotic process which seems secondary , " dr “从概念上讲，系统性硬化是一种以系统性的纤维化变性为特征的严重疾病，早期主要表现在血管性的病变，因此我们推测早期、适量地应用主要作用于血管的药物（如钙离子阻断剂，内皮素拮抗剂，前列环素，磷酸二酯酶抑制剂等）可能可以干预似乎是继发发生的纤维化过程。 ”
