A clinical study on combination of enalapril with spironolactone in patients with congestive heart failure and ventricular arrhythmia 依那普利与螺内酯联合治疗充血性心力衰竭并室性心律失常的临床观察
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The first involves the use of the drugs lisinopril , carvedilol , spironolactone , and losartan to enhance reverse remodelling 第一个阶段包括药物赖诺普利，卡维地洛、螺内酯和洛沙坦的应用，以提高逆转重塑。
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Conclusions : the addition of spironolactone to candesartan has significant beneficial effects on lv reverse remodeling in patients with mild - to - moderate chronic systolic hf 结论：坎地沙坦联合螺内酯治疗对轻中度慢性收缩性心力衰竭患者的lv逆重构有明显益处。
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What you may complain about is that we don ' t have so many trials about diuretic , spironolactone , or other medications , even nitrates in the therapy of hypertension 你可能会抱怨为什么我们没有大量的临床试验来研究治疗高血压所用的螺内酯或者其他药物包括硝酸酯类药物呢？
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Zannad f , alla f , dousset b , et al . limitation of excessive extracellular matric turn over may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure . circulation , 2000 , 102 : 2700 程远植.醛固酮拮抗剂螺内酯在慢性心衰的治疗作用和应用进展.中华心血管杂志, 2003 , 31 : 69 - 71
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Methods : fifty - one systolic hf patients with left ventricular ejection fraction ( lvef ) < 40 % were randomly assigned to receive 1 - year treatment of candesartan and spironolactone ( combination group ) or candesartan and placebo ( control group ) 方法： 51名左室射血分数（ lvef ） < 40 %的收缩性心力衰竭患者随机分配到接受坎地沙坦和螺内酯治疗1年（联合治疗组）或坎地沙坦和安慰剂治疗（对照组） 。
