| 1. | Oncogenic mutations initiate tumorigenesis , but angiogenesis is necessary for expansion of tumor mass
癌基因突变引起肿瘤形成，而血管生成则是肿瘤扩大所必需的。 |
| 2. | Paradoxically , autophagy defects are associated with increased tumorigenesis , but the mechanism behind this has not been determined
自相矛盾的是，自噬缺陷与肿瘤发生的呈正相关，但这背后的机制仍没有被明确。 |
| 3. | Colorectal cancer is one of the most common malignant neoplasms , and apoptotic dysfunction plays an important role in its tumorigenesis and metastasis
摘要大肠癌为常见的恶性肿瘤，细胞凋亡调控失常在其发生和发展中起着重要作用。 |
| 4. | Cancer stem cells are defined as rare cells in cancer tissues with indefinite potential for self - renewal that drives tumorigenesis
摘要肿瘤干细胞是存在于肿瘤组织内数量极少的既保持干细胞自我更新能力又能够导致肿瘤发生、发展的一群细胞。 |
| 5. | Tumor might be a kind of diseases of stem cells , and this finding may help to understand the mechanisms of tumorigenesis and instruct clinical therapeutics
肿瘤可能是一种干细胞疾病，这对认识肿瘤的发病机理和有效的临床治疗具有重要的指导作用。 |
| 6. | Although some diseases occur when both copies of a gene are mutated , mutation of just one copy of certain tumour - suppressor genes promotes tumorigenesis
虽然，一些疾病发生在当一个基因的两个副本均发生突变或者只是某个肿瘤抑制基因的一个副本发生的突变促进了肿瘤的发生发展。 |
| 7. | Studies of cancer stem cell biology and mechanisms of tumorigenesis are lending insight into the origins of cancer and will ultimately yield new approaches to fight cancer
明确肿瘤干细胞的生物学性状及其导致肿瘤发生的内在机制，并以肿瘤干细胞为靶标开展相关研究，就有可能为肿瘤治疗提供新的手段并最终为根治恶性肿瘤带来希望。 |
| 8. | In this paper , we reviewed the study of the significant role of the ubiquitin - proteasome proteolytic pathways during the cell cycle , dna repair and apoptosis , especially the relationship between these pathways and tumorigenesis
通过介绍泛素介导的蛋白质降解途径在细胞周期、 dna修复、细胞凋亡中的作用，系统阐述了泛素介导的蛋白质降解途径与肿瘤发生的关系。 |
| 9. | In most normal tissues , telomerase activity can not be detected or nearly be detected . however , telomerase plays an important role in tumorigenesis and development of malignant tumor , which makes it a possible new target in gene therapy
端粒酶之所以能成为肿瘤治疗的新靶点，在于大多数正常组织中没有活性或活性极低，而在恶性肿瘤的发生、发展中起着关键的作用。 |
| 10. | At the same time , the number of driver mutations was larger than previously anticipated and , interestingly , most of the genes with driver mutations were not previously thought to be involved in tumorigenesis , indicating that more cancer genes exist than just the usual suspects
同时，驱动突变的数目大大超过先前预期的，有趣地是，大多数带有驱动突变的基因在先前被认为是没有在肿瘤发生中起作用，暗示存在更多的癌症基因，远不止一般认为的常见突变。 |
