| 1. | Benzothiazepine derivatives are of great importance in the discovery of lead compounds
摘要在寻找先导化合物的过程中。 |
| 2. | Natural products provide the most important sources of lead compounds in drug discovery
天然产物是药物发现中先导化合物的重要来源。 |
| 3. | Natural products are one of the moat important sources of the lead compounds in drug discovery
天然产物是药物先导化合物的重要来源。 |
| 4. | Natural products provide the most important sources of lead compounds in drug discovery
摘要天然产物是药物发现中先导化合物的重要来源。 |
| 5. | Natural products are one of the moat important sources of the lead compounds in drug discovery
摘要天然产物是药物先导化合物的重要来源。 |
| 6. | Dark purple regions contain a greater acceptor / donor density and light purple regions indicate areas where hydrogen bonding is less likely to occur
经过多次循环,这种先导化合物就会被优化为一组具有高亲和力的结构。 |
| 7. | Conclusion the efficiency for finding of leading compounds could be improved if the isolation is based on metabonomics under the guidence of the new method of botanical mixture determination by 1h - nmr
结论基于植物代谢组学混合物氢谱测定指导下的分离是一种高效发现先导化合物的新方法。 |
| 8. | Abstract : three - dimensional ( 3d ) searching in a database of molecules based on their 3d characteristics has become a fast and effecive approach to discover leading compounds
文摘:利用分子的三维特征，在三维结构数据库中进行三维结构搜索的方法是一种发现先导化合物的快捷而有效的方法，已经得到了广泛的重视。 |
| 9. | Employing diversity - oriented synthesis ( dos ) to construct skeletally complex natural product - like libraries and using it in the studies of chemical biology and lead discovery is becoming a tendency
用多样性导向合成方法建立骨架多样、构造复杂、立体化学多样性的“类天然产物”化合物库进行生物学相关研究，并以此为基础发现药物先导化合物正在成为一种趋势。 |
| 10. | Moreover , because the model can be easily transported through internet , many scientists can share it . the work also prepares to search the idea 3d structures and screens chemical depend on object molecular . it is very important , for the work of drug design
由于其自身具有传输容易的特点，制作的药物分子模型可以实现网络传输，用于在在internet上实现分子3d结构显示，实现了对网络库中活性分子的三维结构的共享，被众多的研究者使用，为实现三维结构搜索，根据靶位的空间结构来筛选活性化合物，对药物先导化合物的发现和分子设计打下坚实的基础。 |
