Notch proteins are a family of evolutionarily conserved transmembrane receptors which are involved in cell fate determination of many cell lineages . notch ligand delta is also transmembrane protein with characteristic cysteine - rich n - terminal domain responsible for notch binding Notch基因广泛表达于胚胎发育过程中的各种组织和各种成熟组织中具有增殖能力的细胞层，该基因编码一个由2753个氨基酸残基的型跨膜蛋白分子受体，其配体也是细胞膜蛋白，称为delta 。
