Novel methods for measurement of intraocular pressure / volume and aqueous fluid production / outflow were applied in comparative studies of wildtype mice vs . mice lacking aqp1 and aqp4 ( individually and together ) . methods : aqueous fluid production was measured by in vivo confbcal microscopy after transcomeal iontophoretic introduction of fluorescein into the aqueous fluid 创造性地设计和建立了小鼠眼房水动力学测量的系统方法，对野生型小鼠和水通道蛋白敲除小鼠的眼内压、房水容积、房水生成和排出等生理特征，分别进行了系统检测和对比分析。
