| 1. | Clinical analysis on adverse reaction of central nervous system induced by fluoroquinolone
氟喹诺酮类药物致中枢神经系统不良反应的临床分析 |
| 2. | Comparison of hepatic toxic injury induced by concomitant use of fluoroguinolones and antituberculotics in mice
氟喹诺酮类联用抗结核药肝毒性比较 |
| 3. | Fluoroquinolones enterprises in china need to revise product lines reasonably based on product strategy and analyzing the competition trends so as to win more superiority in competition
氟喹诺酮类原料药企业需要结合自身产品战略，分析竞争形势，合理调整产品线，以获得更强竞争优势。 |
| 4. | Among outpatient cases , the rate of fluoroquinolone use increased from 35 % to 61 % , whereas the rate of trimethoprim - sulfamethoxazole use decreased from 53 % to 32 % oer the 5 - year period ( p < . 01 )
门诊病人中氟喹诺酮运用在5年期间从35增加到61 ，而甲氧苄氨嘧啶的运用率从53减少至32 ( p < . 01 ) 。 |
| 5. | The prospect of china fluoroquinolones market is not only dependent on the global competition , but also on the opportunity of expiration of patented blockbuster drugs and the trends of renewal of analogous products
我国氟喹诺酮类原料药的市场前景不仅取决于国际的竞争，还在于是否能够把握“重磅炸弹”专利药物过期的契机与同类药物的更迭。 |
| 6. | Pcr fragments of 668bp , containing the quinolone resistance - determining region of the gyra gene got from the whole strains in the cherosome , and the one in the plasmid which were the first found in the salmonella typhimurium that reported in p . r . china
结果表明， 16株致病性沙门氏菌对12种常用抗菌素的耐药率在31 . 3 - 93 . 8之间，并已经出现了氟喹诺酮类耐药菌株。 |
| 7. | A total of 89 salmonella strains were isolated from poultry from beijing , tianjin , shandong etc . the resistance to 12 antimicrobial drugs and 6 fluoroquinolones were detected and analyzed by the broth microdilution method
建立了针对肠杆菌科细菌的耐药性监测方法-微量肉汤稀释法，并用该方法监测和分析了89株禽源沙门氏菌对12种抗菌素和6种氟喹诺酮类药物的耐药性。 |
| 8. | And pcr - rflp analysis was a sensitive , rapid and simple assay for the detection of nucleotide sequence change in ser 83 . and our data sugget that pcr - rflp may be a useful device for detecting the mutation in gyra gene associated the resistance to fqns
本研究通过试验条件的筛选，建立了pcr - rflp检测猪源致病性沙门氏菌gyra基因点突变的方法，可用于沙门氏菌氟喹诺酮类耐药性的分子水平检测和流行病学监测。 |
| 9. | Panipenem and imipenem exhibited comparable in vitro antimicrobial activity , and their activity against gram - negative bacteria such as k . pneumoniae and enterobacter spp was slightly inferior to meropenem , superior to that of ceftazidime , fluroquinolones and - lactam and - lactamase inhibitor combinations
三种碳青霉烯类抗生素体外抗菌作用优于头孢他啶、 -内酰胺类抗生素与-内酰胺酶抑制剂合剂、氟喹诺酮类等其它受试药物。 |
| 10. | The hinf i restriction enzyme digestion gave rise to restriction fragment length polymorphism ( rflp ) of the pcr products . when there were two dna fragments of 363bp and 305bp were produced from a pcr product , the strains were assumed to have a mutation at ser83 , when three fragments of 363bp , 206bp and 99bp were produced , the strains were assumed to have no mutation at the 83or 116 . the results indicated that certain mutation of ser 83 abolished a hinf i restriction enzyme site and may be detected as a rflp
本研究重点分析了16株菌对氟喹诺酮类( fqns )药物的耐药性，结果表明： 16株菌对诺氟沙星、环丙沙星、沙拉沙星、单诺沙星和氧氟沙星等( nor 、 cip 、 sar 、 dan 、 ofl )的耐药率在31 . 3 - 56 . 3之间。 |
