Georgia ' s objects , liza etc , ? shipment central compounds , passo hydrolysis esters manufacturing project planning 奥美格氏物、利扎三唑、吗啉环合物、帕苏水解酯的制造项目的筹建。
2.
Diazaspiro [ 4 . 4 ] nonane was synthesized from malononitrile as the starting material by a series of nucleleophilic displacement , hydrolytic cyclization and carbonyl reduction 摘要以丙二腈为原料，经过亲核取代、水解环合、羰基还原系列反应，合成了2 ， 7 -二氮螺[ 4 . 4 ]壬烷。
3.
The reaction of ethyl allylacetoacetate with polyfluoroalkyl iodides under similar conditions gave the corresponding adducts , which were sequentially treated with base to the cycization products 在相同条件下，烯丙基乙酰乙酸乙酯与多氟烷基碘代烷反应得到相应的加成物，加成物随后用碱处理也得到环合的产物。
4.
Lorazepam was synthesized by the following seven steps : condensation reaction ( 1 ) , condensation reaction ( 2 ) , cyclic reaction , ring expanding reaction , acylate reaction , hydrolysis reaction and refining 摘要详细设计了劳拉西泮的合成路线，主要过程有缩合反应（一） 、缩合反应（二） 、环合反应、扩环反应、酰化重排反应和水解反应。
5.
Mirtazapine was prepared by a seven - step reaction , namely nucleophilic ring - opening reaction , chlorination , cyclization , uncleophilic substitution , hydrolysis , reduction and cyclization from styrene oxide and n - methylethanolamine as the starting materials , with overall yield of 22 . 6 % 摘要以环氧苯乙烯和n -甲基乙醇胺为起始原料，经亲核开环、氯代和环合反应得到中间体1 -甲基3 -苯基哌嗪。
6.
Hydroxyquinol triacetate was prepared from p - benzoquinone by 1 , 4 - addition reaction with acetic anhydride and then 6 , 7 - dihydroxy coumarin was synthesized from it by hydrolyze and cyclization in concentrated sulfuric acid . then 6 , 7 - dimethoxy coumarin was synthesized by methylating from 6 , 7 - dihydroxy coumarin with an overall yield of 74 . 4 % . the procedure was practical . its structure was confirmed by ir and 1hnmr 对苯醌与乙酸酐经1 , 4 -加成生成1 , 2 , 4 -苯三酚三乙酸酯,然后与苹果酸反应经水解、环合反应得6 , 7 -二羟基香豆素,再经甲基化得到6 , 7 -二甲氧基香豆素,总收率为74 . 4 % ,整个过程反应条件温和,操作方便,适合工业生产的要求,对产品结构进行了ir和1hnmr表征。
