The ns5 protein of dengue virus is the largest molecule encoded by the virus genome with a molecule weight of 104 000 . recent research work indicates that the ns5 protein acts as the rna - dependent rna polymerase ( rdrp ) in virus which has the ability to recognize and bind its template rna to synthesize a complementary strand 近年来的研究表明， ns5蛋白具有rna依赖的rna聚合酶( rdrp )功能，即可以识别具有相对特异性的模板rna并与之结合，合成与模板互补的rna链，在病毒基因组复制过程中起关键作用。
